• Engineered to allow young patients to return to active life styles following meniscus injury
  • Designed to restore mobility following degenerative tears
  • Revolutionising orthopaedics and the treatment for meniscus injury

Orthonika is a spin-out company from Imperial College London developing the Total Meniscus Replacement, a unique entirely anatomical replacement for the meniscus of the knee

Meniscus Injury

Meniscus injury can be severely debilitating and may lead to osteoarthritis and the need for knee arthroplasty. Today’s treatment options are very limited resulting in a high unmet need. Partial meniscectomy does not restore full joint biomechanics and is thought to lead to knee osteoarthritis1 2. Partial replacement is only suitable as long as the meniscal rim is intact. Allograft transplantation has severe limitations including donor availability, risk of infection and sizing and is associated with high morbidity and socioeconomic costs.

Man holding knee

Our Innovation

We are developing the Total Meniscus Replacement the first entirely anatomical replacement for the meniscus of the knee. It is being engineered using a unique material structure which replicates the structure function relationship of the natural tissue. The innovative structure uses a novel fibre reinforced structure embedded in a proprietary polymer. The implant is currently in development at the pre-clinical stage.

News & Media

19th May 2017
Orthonika's story has been selected as one of 22 spin-offs featured in this month's Nature Outlooks on 'university spin'offs' (Nature, Volume 545, Issue 7654, S21–S24, 18 May 2017) . To learn more... Read more
15th May 2017
London, UK, 15th May 2017 / Orthonika Limited, a spin-out from Imperial College London, is pleased to announce success in securing funding for development of its novel synthetic total knee meniscus... Read more


  1. Roos et al.1998. Knee osteoarthritis after meniscectomy: prevalence of radiographic changes after twenty-one years, compared with matched controls. Arthritis & Rheumatology, Apr;41(4), pp. 687-93.
  2. Rangger et al. 1995. Osteoarthritis after arthroscopic partial meniscectomy. American Journal of Sports Medicine, 23 (2), pp. 240–244